Therapeutic Strategies for Mutant SPAST-Based Hereditary Spastic Paraplegia

Mutations of the SPAST gene that encodes the microtubule-severing enzyme called spastin are the chief cause of Hereditary Spastic Paraplegia.Growing evidence indicates that pathogenic mutations functionally compromise the spastin protein read more and endow it with toxic gain-of-function properties.With each of these two factors potentially relevant to disease etiology, the present article discusses possible therapeutic strategies that may ameliorate symptoms in patients suffering from SPAST-based Hereditary redken shades eq 07m driftwood Spastic Paraplegia, which is usually termed SPG4-HSP.